LBNL 한인 모임

FB_1.jpgFB_2.jpg


TITLE3D printed absorber for capturing toxic chemotherapy drugs before they spread through the body

 

SPEAKER: Prof. Hee Jeung Oh

 

ABSTRACT

Cancer is becoming the leading cause of death in most westernized nations. Despite efforts to develop increasingly targeted and personalized cancer therapeutics, dosing of drugs in cancer chemotherapy is limited by systemic toxic side effects. During intra-arterial chemotherapy infusion to a target organ, excess drug that is not trapped in the target organ passes through to the veins draining the organ, and is then circulated to the rest of the body, causing toxicities in distant locations. Typically, more than 50-80% of the injected drug is not trapped in the target organ and bypasses the tumor to general circulation.

 

In this context, we have designed, built, and deployed porous absorbers for capturing chemotherapy drugs from the blood stream after these drugs have had their effect on a tumor, but before they are released into the body where they can cause hazardous side effects. The porosity was obtained by 3D printing of lattice structures within a cylinder. The surface of porous cylinders was coated with an ion-containing polymer which is responsible for capturing doxorubicin, a widely used chemotherapy drug with significant toxic side effects. Using a swine model, we show that our initial design enables the capture of 69 % of the administered drug without any immediate adverse effects. Additional improvement in performance may be obtained by changing the chemical composition and thickness of the coating layer, in addition to controlling the lattice structure and size with elastomers. This development represents a significant step forward in minimizing toxic side effects of chemotherapy.

 

BIOHee Jeung Oh is currently a postdoctoral scholar in the Department of Chemical and Biomolecular Engineering at the University of California, Berkeley. She will join the Department of Chemical Engineering in Pennsylvania State University in January, 2020. She earned her bachelor’s degree in Chemical Engineering from the Korea Advanced Institute of Science and Technology (KAIST). Hee Jeung completed her graduate training in Chemical Engineering working in Profs. Benny Freeman’s and Donald Paul’s research groups at the University of Texas at Austin, exploring a variety of polymeric materials for membrane-based separation. She first developed solvent-free, melt-processed, robust ion-exchange membranes based on sulfonated polymers, and evaluated water and salt permeation, sorption, and diffusion in the membranes. Her postdoctoral training, working in Prof. Nitash Balsara’s research group at UC Berkeley, focuses on designing porous nanostructured polymers for energy storage, as well as a new emerging biomedical application, “drug capture,” to minimize toxic side effects of cancer chemotherapy drugs. She first designed and developed a 3D printed absorber for capturing chemotherapy drugs downstream of tumors before they spread through the body and cause the toxic side effects.

번호 제목 글쓴이 날짜 조회 수
공지 UKC 2014 Volunteers needed! orppaha 2014.05.28 10080
공지 LBNL 초기 정착 도우미 서비스 (LBNL Initial Settlement Assistance Service) orppaha 2013.08.01 11113
공지 KSEA Berkeley Chapter 소개 orppaha 2013.07.31 9763
공지 LBNL K-Network orppaha 2013.07.31 9965
31 Unveiling the mechanism of phase evolution and H2 storage/CO2 uptake properties in nanohybride of magnesium borohydride supported by reduced graphene oxide (200124 KSEA Berkeley Chapter Seminar) file 지미버틀러 2020.01.30 553
30 Operando X-ray absorption spectroscopy studies on CO electroreduction reaction (200124 KSEA Berkeley Chapter Seminar) file 지미버틀러 2020.01.30 494
» 3D printed absorber for capturing toxic chemotherapy drugs before they spread through the body (191101 KSEA Berkeley Chapter Seminar) file 지미버틀러 2019.11.09 571
28 2019 Oct. KSEA Berkeley Chapter Happy Hour file 지미버틀러 2019.10.12 1393
27 Aligned carbon nanotube architectures for biomimetic metasurfaces (190807 KSEA Berkeley Chapter Seminar) file 지미버틀러 2019.08.08 816
26 High Throughput Evolution of Near Infrared Serotonin Nanosensors (190807 KSEA Berkeley Chapter Seminar) file 지미버틀러 2019.08.08 955
25 The solid/gas and solid/liquid interface in the catalyst probed with Ambient-pressure X-ray Photoelectron Spectroscopy (190807 KSEA Berkeley Chapter Seminar) file 지미버틀러 2019.08.08 455
24 In-situ Liquid-Phase Transmission Electron Microscopy for Studying Nanocrystal Formation (190605 KSEA Berkeley Seminar) file 지미버틀러 2019.06.05 1269
23 한국산업기술평가관리원 사업설명회 (190605 KSEA Berkeley Seminar) file 지미버틀러 2019.06.05 2077
22 Solid state Li batteries. What is it? and where is it going? (190605 KSEA Berkeley Seminar) file 지미버틀러 2019.06.05 1277
21 2019 Apr. Farewell Dinner for Dr. Shin and Dr. Cho file 지미버틀러 2019.04.11 851
20 Photo-chemistry and -physics of Ir complexes (190410 KSEA Berkeley Chapter Seminar) file 지미버틀러 2019.04.11 893
19 A single-ion conducting borate network polymer as a viable electrolyte for Li-metal batteries (190410 KSEA Berkeley Chapter Seminar) file 지미버틀러 2019.04.11 698
18 Surface and Interfacial Chemistry of Bio-inspired Phenolic Coatings (190213 KSEA Berkeley Chapter Seminar) file 지미버틀러 2019.04.11 651
17 Study on the chemical/electronic structures of organic functional materials by combining photoemission spectroscopy with argon gas cluster ion beam sputtering (181214 KSEA Berkeley Chapter Seminar) file 지미버틀러 2019.04.11 722
16 High Symmetry Ordered Multigrain Nanocrystals to Reveal and Maximize the Effect of Grain Boundary Defects (181018 KSEA Berkeley Chapter Seminar) file 지미버틀러 2019.04.11 753
15 2018 Sep. Farewell Lunch for Dr. Kim file 지미버틀러 2019.04.10 844
14 Development of Innovative materials and process technology: 1. Microreactors for Better Chemical Processes 2. Peptide Self-Assembly (180813 KSEA Berkeley Chapter Seminar) file 지미버틀러 2019.04.10 654
13 2018 July Farewell Dinner for Prof. Kim and Prof. Lee file 지미버틀러 2019.04.10 716
12 2018 May Happy Hour file 지미버틀러 2019.04.10 662