Professor Shuvo Roy, University of California, San Francisco

Bioengineering (BioE)


Spring 2010 Seminar Series

Wednesday, February 24
12noon - 1:00pm
106 Stanley Hall, UC Berkeley

"An Implantable Artificial Kidney using Silicon Nanoporous Membranes"

Shuvo Roy
Department of Biopharmaceutical Sciences
University of California, San Francisco

Abstract:
End stage renal disease (ESRD), or chronic kidney failure, affects over 500,000 Americans and has been increasing in prevalence at 5-8% annually. The treatment of choice, kidney transplant, is severely limited by scarcity of donor organs, such that only 25% of patients on the waiting list for a transplant survive long enough to receive a kidney. The majority of ESRD patients are limited to thrice-weekly, in-center hemodialysis therapy, which is expensive, inconvenient, and confers significant morbidity and mortality. We are developing an artificial kidney that will provide many of the benefits of kidney transplant, including unencumbered patient mobility, freedom from repeated vascular access, and improved physiology and cognitive function, but without the need for immunosuppressive drugs. This implantable device combines hemofiltration through a highly selective membrane barrier with cell therapy using a bioreactor of cultured proximal tubule cells to mimic many of the metabolic, endocrine, and immunological functions of a healthy kidney. The development of the artificial kidney relies on MEMS (microelectromechanical systems) and related nanotechnology strategies to produce biocompatible silicon nanoporous membranes with superior filtration and cell immunoisolation characteristics. The seminar will present the underlying design philosophy, membrane fabrication strategy, and recent in vitro and in vivo testing results to confirm the overall feasibility of the implantable artificial kidney.

Hosted by Professor John Dueber


510-642-5833

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